Evaluation of Serum Ghrelin and Leptin Levels in Patients with Celiac Disease, Type1Diabetes Mellitus and Rheumatoid Arthritis

Ghrelin and leptin are two hormones that possess multiple functions, including appetite regulation, maintenance of the tissue homeostasis regulation proinflammatory cytokines. A few studies on serum ghrelin levels in autoimmune diseases have exhibited conflicting results. Therefore, present study aimed to investigate relationship between energy balance diseases. Serum were assessed 94 adult patients, 61 females 33 males, with various (celiac disease, type 1 diabetes mellitus rheumatoid arthritis) as well 35 healthy people controls, using commercially available ELISA kits. Statistically important distinctions (P < 0.05) found patients controls regard levels. Moreover, had higher mean than males. On other hand, level was positively correlated (r = 0.399, P RA group. Whereas no significant correlation > both CD T1DM groups. As biomarkers (tissue transglutaminase antibodies, anti-tTG; glutamic acid decarboxylase anti-GAD; cyclic citrullinated peptide anti-CCP) ghrelin/leptin revealed anti-CCP only marker significantly associated RA. The current indicates a linkage immune system metabolic depending response different conditions. Additional required understand whether changes ghrelin-leptin influence emergence or vice versa.